FDA Approved First Dengue Vaccine With Some Restrictions

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The vaccine was found effective in 76% individuals among 35000 living in endemic areas with previous dengue infection aged 9 to 16 years.

Common side effects reported with the new vaccine are headache, muscle pain, joint pain, fatigue, etc. These effects decrease after each subsequent dose of the vaccine.

“Dengvaxia appears to act as a first dengue infection — without actually infecting the person with wild-type dengue virus — such that a subsequent infection can result in severe dengue disease,” the FDA says.

Therefore, the FDA advises healthcare professionals to identify individuals for prior dengue infection to avoid vaccinating persons who have not been previously infected by the dengue virus.

Confirmation of the previous infection can be established through a medical record of the patient’s having already had a laboratory-confirmed dengue infection or through serologic testing before vaccination.

Source: Medindia

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